Encapsulation of Active Pharmaceutical Ingredient by Double Emulsion to Control Drug Release for Pulmonary Application

This application note deals with the encapsulation of an active pharmaceutical ingredient (API) in a biocompatible matrix to protect it and to control its release in time. We show that a right control of the formulation parameters allows to adapt the size and the porosity of the particles, the two mains characteristics which control and regulate the drug release kinetic. Double emulsion technology is used by GREEnMat to design these particles and to tailor their properties (size, porosity and percentage of the encapsulation).