Archive : Applications notes
Encapsulation of Active Pharmaceutical Ingredient by Double Emulsion to Control Drug Release for Pulmonary Application
This application note deals with the encapsulation of an active pharmaceutical ingredient (API) in a biocompatible matrix to protect it and to control its release in time. We show that a right control of the formulation parameters allows to adapt the size and the porosity of the particles, the two mains characteristics which control and regulate the drug release kinetic. Double emulsion technology is used by GREEnMat to design these particles and to tailor their properties (size, porosity and percentage of the encapsulation).
From micronic particles to milimetric granules using granulation process
A powder is a material composed of fine solid particles. These particles can vary in size and shape and generally consists of a wide particle size distribution that is inherent to the production mode employed and leads to a non-uniform final product.
The finer the particles are, the more hazardous they are and their manipulation requires the use of fumehoods and adequate personal protection equipment such as FFP2/FFP3 protection masks. This hazard also impacts the transport procedures from the manufacturer to the final user. So, one can be interested in reducing the volume of fine particles in the product.
